BMI identifies high-risk renal transplant patients
Body mass index (BMI) has a number of important associations for kidney transplant recipients (KTRs), say nephrologists at the University of Ferrara in Italy: For one, KTRs are bound to develop cardiovascular disease (CVD), and obesity is a well-known risk factor for CVD. In addition, studies have indicated that the metabolic syndrome (MetS) is a frequent finding in KTRs, and MetS could even develop in patients with an only marginally increased BMI. In the present study, the authors compared the impact of BMI and MetS on the development of major clinical events (MCEs) in a cohort of 107 KTRs.
Patients were classified into 3 groups: normal (BMI < 25 kg/m2), overweight (25-30) and obese (> 30). 55 MCEs were recorded during follow-up (63 months): 16 patients died (15 %), 19 (18 %) had major cardiovascular events (CVEs), and 20 (19 %) started dialysis due to graft failure. Compared to KTRs without MCEs, the 42 KTRs with MCEs were older, had a lower renal function, longer dialysis vintage pre-transplantation, higher prevalence of history of CVD and a higher BMI. The following parameters were related to MCEs: length of dialysis pre-transplantation, renal function, previous CVD, and BMI classes (overweight and obesity).
Clinicians should be able to identify KTRs at high risk for MCEs with a simple evaluation of the patients’ BMI, conclude the authors.