Cardiac output monitoring devices in perioperative medicine

Measuring cardiac output (CO) is essential for the treatment decision-making process in critically ill and high-risk surgical patients. To aid physicians, researchers from Belgium, France, Japan......

Once upon a time: The story of erythropoetin and biosimilars

Anemia is the most common complication of advanced chronic kidney disease (CKD), and the decreased production of erythropoietin (EPO) is the main etiologic factor. The first recombinant human......

Femoral cartilage deformation: Walking just as “bad” as running

Orthopedics mainly have to deal with damaged cartilage. By contrast, orthopedics at the University of North Carolina decided to focus on cartilage deformation in healthy individuals: The present......

Cardiac output monitoring devices in perioperative medicine

Measuring cardiac output (CO) is essential for the treatment decision-making process in critically ill and high-risk surgical patients. To aid physicians, researchers from Belgium, France, Japan......

Once upon a time: The story of erythropoetin and biosimilars

Anemia is the most common complication of advanced chronic kidney disease (CKD), and the decreased production of erythropoietin (EPO) is the main etiologic factor. The first recombinant human......

Femoral cartilage deformation: Walking just as “bad” as running

Orthopedics mainly have to deal with damaged cartilage. By contrast, orthopedics at the University of North Carolina decided to focus on cartilage deformation in healthy individuals: The present......

Circulating cancer cells: Useful predictors for therapy effects and metastasis

Dissemination of tumor cells mostly occurs through the blood, which is why circulating tumor cells (CTC) are particularly interesting regarding the prediction of treatment success and prognosis.......

Pressure for prone positional patients

Positional apparatuses used for the prone position can affect intra-abdominal pressure (IAP). In the present study, South Korean anesthetists from the Seoul National University College of Medicine...

Cocaine, opiates and chronic kidney disease

Illegal drug use is endemic in the United States, with more than half of adolescents and adults reporting having taken illegal drugs during their lifetime. The adverse effects of such drug use on......

Knee OA: Analgesics increase risk of falls

Analgesics are commonly used to combat pain in knee osteoarthritis (OA), but there is not enough data on the risk of falls when using the drugs – in particular with respect to the risk of......

One pathologist = Two opinions

No, this study is not about pathologists with split personalities. The actual question at the center of the present study by researchers at the University of Washington School of Medicine was:......

Perioperative glucocorticoids are safe

Glucocorticoids are used with an “exponential growth” in the perioperative setting for an ever-growing number of indications – most notably to prevent nausea and vomiting, say researchers from......

Canagliflozin: Renoprotective regardless of glycemic effects

Canagliflozin is a sodium-glucose cotransporter 2-inhibitor that has been shown to decrease HbA1c, body weight, BP, and albuminuria in patients with diabetes. These results imply a possible......

The femur, the fracture and the nail

What is the incidence of proximal femoral shortening (PFS) when intertrochanteric fractures are treated with a cephalomedullary nail (CMN)? What are the effects of PFS on patient outcomes?......

Gallbladder cancer: Re-resect after 4 to 8 weeks

Guidelines currently recommend (select) patients with incidentally discovered gallbladder cancer to undergo re-resection after initial cholecystectomy. However, the optimal time interval for this......

Fluid management and how it affects acute kidney injury

What are the ramifications of different fluid management strategies on renal outcomes in critically ill and postoperative patients? So far, it has been shown that uncritical fluid administration......

Hemodiafiltration, hemodialysis and the heart

Hemodialysis = cardiac strain: The hemodynamic stress experienced during hemodialysis (HD) results in recurrent segmental ischemic injury (myocardial stunning), and this in turn drives cumulative......

Tilt, lordosis and disability

Global tilt (GT) and lumbar lordosis index (LLI) are two parameters that have been correlated with health-related quality of life (HRQoL) scores. But how exactly do these factors impact......

Prophylactic mesh reduces hernia rate

Parastomal hernias (PSH) are the most frequent complication after stoma formation. The patient may experience symptoms ranging from mild abdominal pain to life-threatening obstruction and......

Ketamin: Paradoxes, bursts and recoveries

How to improve recovery from general anesthesia has long been a focus of research. Recently, scientists have started to investigate an approach that promotes arousal by manipulating certain brain......

Stage 3-4 CKD: Cut the salt

Patients with chronic kidney disease (CKD) are often volume expanded and hypertensive. Could a sodium-restricted diet (SRD) help? Yes, say researchers at the University of Michigan, Ann Arbor:......

Knee joint degeneration in juvenile discoid lateral meniscus

Two treatment options for discoid lateral meniscus (DLM) are arthroscopic meniscal reshaping and total / subtotal meniscectomy. Of these, meniscal reshaping leads to better outcomes, but some......

Pancreatoduodenectomy: How to avoid the drain

For patients with jaundice and periampullary malignancy, studies have indicated that preoperative biliary drainage (PBD) causes more harm than an approach of “straight to surgery”, say researchers...

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